Publikationen

2022, clinical study: Donor Site Defect Coverage of the Forearm with Dermal Substitute After Harvesting Radial Forearm Free Flap for Phalloplasty: Is MatriDerm® Worth the Effort?

 

This study shows good results for MatriDerm compared to FTG in radial forearm donor sites. It demonstrates that with MatriDerm you get full thickness quality with less morbidity. Radial forearm donor sites are a good indication for MatriDerm with excellent results. The aim of this study was to evaluate if the use of MatriDerm® on the donor site significantly decreases the incidence of complications, such as wound healing disorders and reoperation rate, and if it could shortens the duration of hospital stay.


A clinical study: Dermal regeneration in native non-cross-linked collagen sponges with different extracellular matrix molecules. Reduced wound contraction & scar formation.

 

In a porcine wound model and in a human punch biopsy wound model dermal regeneration of full-thickness skin wounds after implantation of collagenous matrices were studied. Native collagen matrices with elastin reduced the amount of fibroblasts and myofibroblasts, lead to a more randomized collagen fibre orientation, and ontributed to dermal regeneration and reduced wound contraction.

2020: BIOLOGICAL DERMAL TEMPLATES WITH NATIVE COLLAGEN SCAFFOLDS PROVIDE GUIDING RIDGES FOR INVADING CELLS AND MAY PROMOTE STRUCTURED DERMAL WOUND HEALING

 

Successful wound healing depends on carefully orchestrated cellular and physiological processes at the host-biomaterial interface

There are different properties a dermal substitute has to fulfil to enhance tissue regeneration

The degradation of biodegradable natural materials needs to follow the dynamics of the wound repair, guaranteeing the physiological healing evolution, and releasing active principles when needed